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Mol Cell. 2016 Feb 4;61(3):325-326. doi: 10.1016/j.molcel.2016.01.022.

To Cut or Not to Cut: Discovery of a Novel Regulator of DNA Break Resection.

Author information

1
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: james.daley@yale.edu.
2
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

Nucleolytic resection of DNA double-strand breaks is the crucial first step in their repair via homologous recombination. New findings by Tkáč et al. (2016) published in this issue of Molecular Cell identify HELB as a novel, cell-cycle-specific negative regulator of DNA end resection.

PMID:
26849190
DOI:
10.1016/j.molcel.2016.01.022
[Indexed for MEDLINE]
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