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Cell Mol Life Sci. 2016 Apr;73(8):1547-67. doi: 10.1007/s00018-016-2134-0. Epub 2016 Feb 5.

Specification and function of hemogenic endothelium during embryogenesis.

Author information

1
Departments of Medicine, Genetics and Biomedical Engineering, Yale Cardiovascular Research Center, Vascular Biology and Therapeutics Program, and Yale Stem Cell Center, Yale University School of Medicine, 300 George St., New Haven, CT, 06511, USA.
2
Department of Pediatrics, Section of Neonatal-Perinatal Medicine, Yale University School of Medicine, 333 Cedar St., New Haven, CT, 06511, USA.
3
Departments of Medicine, Genetics and Biomedical Engineering, Yale Cardiovascular Research Center, Vascular Biology and Therapeutics Program, and Yale Stem Cell Center, Yale University School of Medicine, 300 George St., New Haven, CT, 06511, USA. karen.hirschi@yale.edu.

Abstract

Hemogenic endothelium is a specialized subset of developing vascular endothelium that acquires hematopoietic potential and can give rise to multilineage hematopoietic stem and progenitor cells during a narrow developmental window in tissues such as the extraembryonic yolk sac and embryonic aorta-gonad-mesonephros. Herein, we review current knowledge about the historical and developmental origins of hemogenic endothelium, the molecular events that govern hemogenic specification of vascular endothelial cells, the generation of multilineage hematopoietic stem and progenitor cells from hemogenic endothelium, and the potential for translational applications of knowledge gained from further study of these processes.

KEYWORDS:

Developmental hematopoiesis; Embryogenesis; Endothelial to hematopoietic transition; Hemogenic endothelium

PMID:
26849156
PMCID:
PMC4805691
DOI:
10.1007/s00018-016-2134-0
[Indexed for MEDLINE]
Free PMC Article
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