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Nature. 2016 Jan 21;529(7586):307-15. doi: 10.1038/nature17039.

Reparative inflammation takes charge of tissue regeneration.

Author information

1
Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, Moores Cancer Center, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0636, USA.
2
Princess Máxima Center and Hubrecht Institute, Uppsalalaan 8, 3584 CR Utrecht, the Netherlands.
3
University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.

Abstract

Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link inflammation to damage repair and regeneration in mammals are conserved in lower organisms, indicating that it is an evolutionarily important process. Recent insights have shed light on the cellular and molecular processes through which conventional inflammatory cytokines and Wnt factors control mammalian tissue repair and regeneration. This is particularly important for regeneration in the gastrointestinal system, especially for intestine and liver tissues in which aberrant and deregulated repair results in severe pathologies.

PMID:
26791721
PMCID:
PMC5228603
DOI:
10.1038/nature17039
[Indexed for MEDLINE]
Free PMC Article

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