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Eur Radiol. 2016 Oct;26(10):3474-82. doi: 10.1007/s00330-015-4197-y. Epub 2016 Jan 15.

Evaluation of 70-150-μm doxorubicin-eluting beads for transcatheter arterial chemoembolization in the rabbit liver VX2 tumour model.

Author information

1
The Russell H. Morgan Department of Radiology and Radiological Science, Division of Interventional Radiology, The Johns Hopkins Hospital, Sheikh Zayed Tower, Suite 7203, 1800 Orleans Street, Baltimore, MD, 21287, USA.
2
Department of Radiology and Biomedical Imaging, Yale University School of Medicine, PO Box 208042, 330 Cedar Street, New Haven, CT, 06520, USA. jeff.geschwind@yale.edu.

Abstract

AIM:

To evaluate the pharmacokinetic profile (PK) and embolization effect of 70-150-μm doxorubicin eluting beads (DEBs) following intra-arterial injection (i.a.) in the rabbit liver VX2 tumour model.

MATERIALS AND METHODS:

In this ACUC-approved study, 25 white New Zealand rabbits were randomly assigned into a small DEB group (SDB, n = 7, 70-150-μm DEBs), large DEB group (LDB, n = 7, 100-300-μm DEBs), untreated controls (n = 7), and doxorubicin controls (n = 4, without tumour, received i.a. 12.5 mg doxorubicin). Plasma PK was assessed up to 180 min post-injection. Drug tissue and liver enzyme levels, radiologic tumor response and histopathologic tumour necrosis were assessed at 7 days.

RESULTS:

Mean tumour doxorubicin concentrations were 922.83 nM (SD = 722.05) and 361.48 nM (SD = 473.23) for the SDB and LDB, respectively (p = 0.005). There was no statistically significant difference in tumour doxorubicinol, plasma doxorubicin and doxorubicinol PK values. More beads were observed in the SDB tumours (p = 0.01). Liver enzymes increased and gradually declined over the observation period, with significantly higher values in the SDB.

CONCLUSION:

In this preclinical study, plasma PK of i.a.-injected 70-150-μm DEBs was not different than that of 100-300-μm DEBs. More beads and higher tissue doxorubicin levels were observed in the SDB tumours.

KEY POINTS:

• Small and large doxorubicin-eluting beads show similar plasma pharmacokinetic profiles. • Higher tissue doxorubicin levels were observed in the small bead group. • Liver enzymes were overall significantly higher in the small bead group.

KEYWORDS:

Doxorubicin; Drug-eluting beads, DEBs; Injections, intra-arterial; Liver neoplasms; Microspheres

PMID:
26780638
PMCID:
PMC4947033
[Available on 2017-10-01]
DOI:
10.1007/s00330-015-4197-y
[Indexed for MEDLINE]
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