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J Control Release. 2016 Oct 28;240:302-311. doi: 10.1016/j.jconrel.2016.01.005. Epub 2016 Jan 8.

Nanotechnology for delivery of peptide nucleic acids (PNAs).

Author information

1
Department of Therapeutic Radiology, Yale University, New Haven, CT, USA.
2
Department of Biomedical Engineering, Yale University, New Haven, CT, USA; Department of Chemical Engineering, Indian Institute of Technology-Delhi, New Delhi, India.
3
Department of Therapeutic Radiology, Yale University, New Haven, CT, USA; Department of Genetics, Yale University, New Haven, CT, USA. Electronic address: peter.glazer@yale.edu.
4
Department of Biomedical Engineering, Yale University, New Haven, CT, USA. Electronic address: mark.saltzman@yale.edu.

Abstract

Over the past three decades, peptide nucleic acids have been employed in numerous chemical and biological applications. Peptide nucleic acids possess enormous potential because of their superior biophysical properties, compared to other oligonucleotide chemistries. However, for therapeutic applications, intracellular delivery of peptide nucleic acids remains a challenge. In this review, we summarize the progress that has been made in delivering peptide nucleic acids to intracellular targets. In addition, we emphasize recent nanoparticle-based strategies for efficient delivery of conventional and chemically-modified peptides nucleic acids.

KEYWORDS:

Antisense therapy; Gene editing; Nanoparticles; Peptide nucleic acids

PMID:
26776051
PMCID:
PMC5016210
DOI:
10.1016/j.jconrel.2016.01.005
[Indexed for MEDLINE]
Free PMC Article

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