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Cell Host Microbe. 2016 Jan 13;19(1):9-11. doi: 10.1016/j.chom.2015.12.015.

Autophagy Snuffs a Macrophage's Inner Fire.

Author information

1
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
2
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: akiko.iwasaki@yale.edu.

Abstract

Autophagy is a well-known cell-intrinsic antiviral defense mechanism. Two new studies published in this issue of Cell Host & Microbe (Lu et al., 2016; Park et al., 2016) demonstrate that deletion of autophagy in myeloid cells leads paradoxically to better control of viral infection in vivo through enhanced inflammation, leading to antiviral resistance.

PMID:
26764592
DOI:
10.1016/j.chom.2015.12.015
[Indexed for MEDLINE]
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