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PLoS Negl Trop Dis. 2015 Dec 31;9(12):e0004260. doi: 10.1371/journal.pntd.0004260. eCollection 2015 Dec.

Quantifying Poverty as a Driver of Ebola Transmission.

Author information

1
Community-Based Initiative, Ministry of Health, Monrovia, Liberia.
2
National Institute of Allergy and Infectious Diseases, PREVAIL-III Study, Monrovia, Liberia.
3
A.M. Dogliotti College of Medicine, University of Liberia, Monrovia, Liberia.
4
Center for Infectious Disease Modeling and Analysis, Yale School of Public Health, New Haven, Connecticut, United States of America.
5
Department of Industrial Engineering, Tel Aviv University, Tel Aviv, Israel.

Abstract

BACKGROUND:

Poverty has been implicated as a challenge in the control of the current Ebola outbreak in West Africa. Although disparities between affected countries have been appreciated, disparities within West African countries have not been investigated as drivers of Ebola transmission. To quantify the role that poverty plays in the transmission of Ebola, we analyzed heterogeneity of Ebola incidence and transmission factors among over 300 communities, categorized by socioeconomic status (SES), within Montserrado County, Liberia.

METHODOLOGY/PRINCIPAL FINDINGS:

We evaluated 4,437 Ebola cases reported between February 28, 2014 and December 1, 2014 for Montserrado County to determine SES-stratified temporal trends and drivers of Ebola transmission. A dataset including dates of symptom onset, hospitalization, and death, and specified community of residence was used to stratify cases into high, middle and low SES. Additionally, information about 9,129 contacts was provided for a subset of 1,585 traced individuals. To evaluate transmission within and across socioeconomic subpopulations, as well as over the trajectory of the outbreak, we analyzed these data with a time-dependent stochastic model. Cases in the most impoverished communities reported three more contacts on average than cases in high SES communities (p<0.001). Our transmission model shows that infected individuals from middle and low SES communities were associated with 1.5 (95% CI: 1.4-1.6) and 3.5 (95% CI: 3.1-3.9) times as many secondary cases as those from high SES communities, respectively. Furthermore, most of the spread of Ebola across Montserrado County originated from areas of lower SES.

CONCLUSIONS/SIGNIFICANCE:

Individuals from areas of poverty were associated with high rates of transmission and spread of Ebola to other regions. Thus, Ebola could most effectively be prevented or contained if disease interventions were targeted to areas of extreme poverty and funding was dedicated to development projects that meet basic needs.

PMID:
26720278
PMCID:
PMC4697799
DOI:
10.1371/journal.pntd.0004260
[Indexed for MEDLINE]
Free PMC Article
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