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Histol Histopathol. 2016 Jun;31(6):601-12. doi: 10.14670/HH-11-718. Epub 2015 Dec 30.

Advances in the knowledge of breast cancer stem cells. A review.

Author information

1
Functional Genomics Laboratory, National Institute of Genomic Medicine, Col. Arenal Tepepan, Delegación Tlalpan and National Autonomous University of Mexico, Mexico City, México.
2
Functional Genomics Laboratory, National Institute of Genomic Medicine, Col. Arenal Tepepan, Delegación Tlalpan, Mexico City, México.
3
Functional Genomics Laboratory, National Institute of Genomic Medicine, Col. Arenal Tepepan, Delegación Tlalpan, Mexico City, México. jmelendez@inmegen.gob.mx.

Abstract

Much effort has been made by researchers to elucidate the complex biology of breast cancer stem cells (BCSCs), a small subset of breast tumor cells that display stem cell properties, drive tumor initiation, and growth. In recent years, it has been suggested that BCSCs could be responsible for the process of metastasis and the development of drug resistance. These findings make the need to find the distinguishing blend of markers that can recognize only BCSCs of the utmost importance in order to be able to design new targeted therapies. This review will summarize BCSCs' main features as well as the cell surface markers that are currently used to identify them.

PMID:
26715540
DOI:
10.14670/HH-11-718
[Indexed for MEDLINE]

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