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Mol Biol Cell. 2016 Jan 1;27(1):7-11. doi: 10.1091/mbc.E14-11-1522.

Biomechanics of vascular mechanosensation and remodeling.

Author information

1
Yale Cardiovascular Research Center, Department of Internal Medicine.
2
Yale Cardiovascular Research Center, Department of Internal Medicine Department of Cell Biology, Yale University, New Haven, CT 06511 Department of Biomedical Engineering, Yale University, New Haven, CT 06511 martin.schwartz@yale.edu.

Abstract

Flowing blood exerts a frictional force, fluid shear stress (FSS), on the endothelial cells that line the blood and lymphatic vessels. The magnitude, pulsatility, and directional characteristics of FSS are constantly sensed by the endothelium. Sustained increases or decreases in FSS induce vessel remodeling to maintain proper perfusion of tissue. In this review, we discuss these mechanisms and their relevance to physiology and disease, and propose a model for how information from different mechanosensors might be integrated to govern remodeling.

PMID:
26715421
PMCID:
PMC4694763
DOI:
10.1091/mbc.E14-11-1522
[Indexed for MEDLINE]
Free PMC Article

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