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Future Oncol. 2016 Jan;12(2):183-98. doi: 10.2217/fon.15.242. Epub 2015 Dec 14.

Sociodemographic impact on survival in unresectable hepatocellular carcinoma: a survival epidemiology and end results study.

Author information

1
Department of Radiology & Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
2
Department of Diagnostic Radiology, Division of Interventional Radiology, Yale University School of Medicine, New Haven, CT 06519, USA.
3
Department of Health Policy & Management, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
4
Yale Cancer Center, Yale University, New Haven, CT 06520-8028, USA.

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Abstract

AIM:

To investigate outcomes in unresectable hepatocellular carcinoma (HCC) patients stratified by sociodemographic and clinical factors in a population study.

MATERIALS & METHODS:

Surveillance, Epidemiology and End Results (SEER) database was used to identify patients diagnosed in 2000-2011. Overall survival (OS) was stratified using patient sociodemographic characteristics and American Joint Commission on Cancer (AJCC) staging. Log-rank test and Cox proportional hazard models were used to identify prognostic factors of OS.

RESULTS:

In patients with AJCC stage I and II unresectable HCC, prolonged OS was correlated with being married, younger age, ethnicity, geographic location, living in large urban areas, being insured and higher income and education levels.

CONCLUSION:

In AJCC stage I and II unresectable HCC patients with favorable sociodemographic factors, prolonged OS maybe in part related to better access to cancer-directed therapy.

KEYWORDS:

HCC; SEER; access to care; cancer-directed therapy; demographic; disparity; socioeconomic; survival; unresectable

PMID:
26690268
DOI:
10.2217/fon.15.242
[Indexed for MEDLINE]
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