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J Assist Reprod Genet. 2016 Jan;33(1):123-8. doi: 10.1007/s10815-015-0629-5. Epub 2015 Dec 16.

ART results with frozen oocytes: data from the Italian ART registry (2005-2013).

Author information

1
Department of Gynaecology, Division of Gynaecology and Reproductive Medicine, Humanitas Fertility Center, Humanitas Research Hospital, Rozzano, Milan, Italy. paolo.levi_setti@humanitas.it.
2
Tecnobios Procreazione, Bologna, Italy.
3
Department of Obstetrics, Gynaecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT, USA.
4
ART Italian National Register, National Centre for Epidemiology, Surveillance and Health Promotion, National Health Institute, Rome, Italy.

Abstract

PURPOSE:

This study is a retrospective collection of aggregated data from all the Italian ART centers reporting to the Italian National Register from cycles started between January 2005 and December 2013.

METHODS:

Data from both slow freezing (SF) and vitrification (V) were assessed for the period 2007-2013, while during the years 2005-2006 cryopreservation was exclusively performed by SF.

RESULTS:

In the study period, a total of 2,526,024 oocytes were retrieved (from 378,543 retrievals), of which 1,346,061 (53.3 %) were inseminated in fresh cycles and 214,481 (8.5 %) were cryopreserved. Cryopreserved oocytes were used in 24,173 cycles yielding 19,453 transfer cycles (80.5 % of the thawing/warming cycles) and 3043 clinical pregnancies (15.6 % per transfer). A significant difference in implantation (8.7 vs 12.9 % OR 1.30 CI 1.20-1.40) and pregnancy rates per transfer (12.2 vs 14.9 % OR 1.34 CI 1.23-1.46) was found between SF and V. Complete outcome data was available for 2708 pregnancies (89.8 %), leading to 1882 deliveries and 2152 live births. Neonatal major congenital anomalies were 0.9 % (20/2152).

CONCLUSIONS:

A wide variation in pregnancy rates were found among different centers and lower rates were reported in donor cycles and in centers with more experience.

KEYWORDS:

ART registry; Congenital anomalies; Cumulative ART pregnancy rate; Oocyte freezing; Safety in ART

PMID:
26676654
PMCID:
PMC4717137
DOI:
10.1007/s10815-015-0629-5
[Indexed for MEDLINE]
Free PMC Article

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