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Elife. 2015 Dec 10;4. pii: e09102. doi: 10.7554/eLife.09102.

NG2 glia are required for vessel network formation during embryonic development.

Author information

1
Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
2
INSERM U1050, Collège de France, Paris, France.

Abstract

The NG2(+) glia, also known as polydendrocytes or oligodendrocyte precursor cells, represent a new entity among glial cell populations in the central nervous system. However, the complete repertoire of their roles is not yet identified. The embryonic NG2(+) glia originate from the Nkx2.1(+) progenitors of the ventral telencephalon. Our analysis unravels that, beginning from E12.5 until E16.5, the NG2(+) glia populate the entire dorsal telencephalon. Interestingly, their appearance temporally coincides with the establishment of blood vessel network in the embryonic brain. NG2(+) glia are closely apposed to developing cerebral vessels by being either positioned at the sprouting tip cells or tethered along the vessel walls. Absence of NG2(+) glia drastically affects the vascular development leading to severe reduction of ramifications and connections by E18.5. By revealing a novel and fundamental role for NG2(+) glia, our study brings new perspectives to mechanisms underlying proper vessels network formation in embryonic brains.

KEYWORDS:

NG2+ glia; Nkx2.1; OPCs; angiogenesis; mouse; neuroscience; polydendrocyte

PMID:
26651999
PMCID:
PMC4764555
DOI:
10.7554/eLife.09102
[Indexed for MEDLINE]
Free PMC Article

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