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J Neurosurg Pediatr. 2016 Apr;17(4):434-8. doi: 10.3171/2015.8.PEDS15313. Epub 2015 Dec 4.

Adjuvant hypofractionated partial-brain radiation therapy for pediatric Ewing sarcoma brain metastases: case report.

Author information

1
Departments of 1 Therapeutic Radiology.
2
Pathology.
3
Neurosurgery, Section of Pediatric Neurosurgery, and.
4
Pediatrics, Section of Pediatric Hematology and Oncology, Yale School of Medicine, New Haven, Connecticut.

Abstract

This case report demonstrates that hypofractionated partial-brain radiation therapy with limited margins is a reasonable approach following gross tumor resection of Ewing sarcoma metastases to the brain. The patient presented with 2 intracranial metastases treated with gross-total resection followed by radiation therapy to 30 Gy in 5 fractions. The patient experienced symptomatic treatment-related inflammatory changes with resolution after receiving dexamethasone. He remains alive at 21 months of follow-up with no evidence of disease.

KEYWORDS:

Ewing sarcoma; GTR = gross-total resection; WBRT = whole-brain radiation therapy; brain metastases; oncology; radiation necrosis; radiation therapy

PMID:
26636250
DOI:
10.3171/2015.8.PEDS15313
[Indexed for MEDLINE]

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