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Front Neural Circuits. 2015 Nov 9;9:73. doi: 10.3389/fncir.2015.00073. eCollection 2015.

Control of Sleep by Dopaminergic Inputs to the Drosophila Mushroom Body.

Author information

1
Department of Cellular and Molecular Physiology, Yale University School of Medicine New Haven, CT, USA ; Janelia Research Campus, Howard Hughes Medical Institute Ashburn, VA, USA.
2
Janelia Research Campus, Howard Hughes Medical Institute Ashburn, VA, USA.
3
Department of Cellular and Molecular Physiology, Yale University School of Medicine New Haven, CT, USA ; Janelia Research Campus, Howard Hughes Medical Institute Ashburn, VA, USA ; Department of Genetics, Yale University School of Medicine New Haven, CT, USA ; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine New Haven, CT, USA.

Abstract

The Drosophila mushroom body (MB) is an associative learning network that is important for the control of sleep. We have recently identified particular intrinsic MB Kenyon cell (KC) classes that regulate sleep through synaptic activation of particular MB output neurons (MBONs) whose axons convey sleep control signals out of the MB to downstream target regions. Specifically, we found that sleep-promoting KCs increase sleep by preferentially activating cholinergic sleep-promoting MBONs, while wake-promoting KCs decrease sleep by preferentially activating glutamatergic wake-promoting MBONs. Here we use a combination of genetic and physiological approaches to identify wake-promoting dopaminergic neurons (DANs) that innervate the MB, and show that they activate wake-promoting MBONs. These studies reveal a dopaminergic sleep control mechanism that likely operates by modulation of KC-MBON microcircuits.

KEYWORDS:

Drosophila melanogaster; dopamine; mushroom body; sleep; synaptic plasticity

PMID:
26617493
PMCID:
PMC4637407
DOI:
10.3389/fncir.2015.00073
[Indexed for MEDLINE]
Free PMC Article
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