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NMR Biomed. 2016 Sep;29(9):1222-30. doi: 10.1002/nbm.3440. Epub 2015 Nov 25.

Proton observed phosphorus editing (POPE) for in vivo detection of phospholipid metabolites.

Author information

1
Department of Radiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
2
Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
3
Department of Radiology, Maastricht University, Maastricht, The Netherlands.
4
Department of Diagnostic Radiology, Yale University, New Haven, CT, USA.

Abstract

The purpose of this article was to compare the sensitivity of proton observed phosphorus editing (POPE) with direct (31) P MRS with Ernst angle excitation for (1) H-(31) P coupled metabolites at 7 T. POPE sequences were developed for detecting phosphocholine (PC), phosphoethanolamine (PE), glycerophosphocholine (GPC), and glycerophosphoethanolamine (GPE) on the (1) H channel, thereby using the enhanced sensitivity of the (1) H nuclei over (31) P detection. Five healthy volunteers were examined with POPE and (31) P-MRS. POPE editing showed a more than doubled sensitivity in an ideal phantom experiment as compared with direct (31) P MRS with Ernst angle excitation. In vivo, despite increased relaxation losses, significant gains in signal-to-noise ratio (SNR) of 30-40% were shown for PE and GPE + PC levels in the human brain. The SNR of GPC was lower in the POPE measurement compared with the (31) P-MRS measurement. Furthermore, selective narrowband editing on the (31) P channel showed the ability to separate the overlapping GPE and PE signals in the (1) H spectrum. POPE can be used for enhanced detection of (1) H-(31) P coupled metabolites in vivo. Copyright © 2015 John Wiley & Sons, Ltd.

KEYWORDS:

POPE; brain; in vivo; phospholipids; proton observed phosphorus editing

PMID:
26601921
DOI:
10.1002/nbm.3440
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