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Psychiatr Q. 2016 Sep;87(3):445-64. doi: 10.1007/s11126-015-9399-6.

Anxiety Disorder-Specific Predictors of Treatment Outcome in the Coordinated Anxiety Learning and Management (CALM) Trial.

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Connecticut Mental Health Center and the Yale Child Study Center, 230 South Frontage Road, New Haven, CT, USA.
Child Study Center, Yale University School of Medicine, PO Box 207900, New Haven, CT, 06520, USA.
Hannover Medical School, Carl-Neuberg Strasse 1, Hannover, 30625, Germany.
Yale Child Study Center and the Department of Psychiatry of Yale University, 230 South Frontage Road, New Haven, CT, USA.


Identifying baseline characteristics associated with treatment outcome in generalized anxiety disorder, panic disorder, social anxiety disorder (SAD) or post-traumatic stress disorder. We performed two secondary analyses of the Coordinated Anxiety Learning and Management trial. Baseline characteristics and their interactions with treatment assignment were analyzed via stepwise logistic regression models and receiver-operating criterion analyses by disorder predicting remission and response for each disorder. Predictors for poor outcome across diagnoses were comorbid depression and low socioeconomic status. Good outcome was associated with positive treatment expectancy and high self-efficacy expectancy. SAD had the lowest rate of remission and response compared to the other anxiety disorders, and differed in respect to its predictors of treatment outcome. Perceived social support predicted treatment outcome in SAD. The special role of SAD among the other anxiety disorders requires further study both because of its worse prognosis and its more specific treatment needs.


Anxiety disorders; Generalized anxiety disorder; Panic disorder; Post-traumatic stress disorder; Social anxiety disorder; Treatment outcome

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