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Curr Mol Biol Rep. 2015 Sep;1(3):101-109. Epub 2015 Jul 12.

Adipose Tissue Residing Progenitors (Adipocyte Lineage Progenitors and Adipose Derived Stem Cells (ADSC).

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Department of Orthopaedics and Rehabiliation, Yale School of Medicine, New Haven, CT 06510.
Department of Molecular, Cell and Developmental Biology, Yale University and the Section of Comparative Medicine, Yale School of Medicine, 375 Congress Avenue, New Haven, CT 06510.
The Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, Maine 04074.


The formation of brown, white and beige adipocytes have been a subject of intense scientific interest in recent years due to the growing obesity epidemic in the United States and around the world. This interest has led to the identification and characterization of specific tissue resident progenitor cells that give rise to each adipocyte population in vivo. However, much still remains to be discovered about each progenitor population in terms of their "niche" within each tissue and how they are regulated at the cellular and molecular level during healthy and diseased states. While our knowledge of brown, white and beige adipose tissue is rapidly increasing, little is still known about marrow adipose tissue and its progenitor despite recent studies demonstrating possible roles for marrow adipose tissue in regulating the hematopoietic space and systemic metabolism at large. This chapter focuses on our current knowledge of brown, white, beige and marrow adipose tissue with a specific focus on the formation of each tissue from tissue resident progenitor cells.


adipocyte progenitors; adipocytes; brown fat; differentiation; marrow fat; white fat

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