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Allergy. 2016 Feb;71(2):210-9. doi: 10.1111/all.12790. Epub 2015 Nov 23.

Allergic manifestation 15 years after early intervention with hydrolyzed formulas--the GINI Study.

Author information

1
Department of Pediatrics, Marien-Hospital Wesel, Research Institute, Wesel, Germany.
2
Institute of Epidemiology I, Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
3
Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany.
4
Department of Pediatrics, Technical University of Munich, Munich, Germany.
5
IUF - Leibniz Research Institute for Environmental Medicine at the Heinrich-Heine-University, Düsseldorf, Germany.
6
Medical Faculty, Deanery of Medicine, Heinrich-Heine University, Düsseldorf, Germany.
7
LVA Oberbayern, Munich, Germany.
8
Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, University of Munich Medical Center, Munich, Germany.

Abstract

BACKGROUND:

Data on the long-term impact of hydrolyzed formulas on allergies are scarce.

OBJECTIVE:

To assess the association between early intervention with hydrolyzed formulas in high-risk children and allergic outcomes in adolescence.

METHODS:

GINI trial participants (n = 2252) received one of four formulas in the first four months of life as breastmilk substitute if necessary: partial or extensive whey hydrolyzate (pHF-W, eHF-W), extensive casein hydrolyzate (eHF-C) or standard cow's milk formula (CMF) as reference. Associations between these formulas and the cumulative incidence and prevalence of parent-reported physician-diagnosed asthma, allergic rhinitis (AR) and eczema, as well as spirometric indices and sensitization, were examined using generalized linear models.

RESULTS:

Between 11 and 15 years, the prevalence of asthma was reduced in the eHF-C group compared to CMF (odds ratio (OR) 0.49, 95% confidence interval (CI) 0.26-0.89), which is consistent with the spirometric results. The cumulative incidence of AR was lower in eHF-C (risk ratio (RR) 0.77, 95% CI 0.59-0.99]) and the AR prevalence in pHF-W (OR 0.67, 95% CI 0.47-0.95) and eHF-C (OR 0.59, 95% CI 0.41-0.84). The cumulative incidence of eczema was reduced in pHF-W (RR 0.75, 95% CI 0.59-0.96) and eHF-C (RR 0.60, 95% CI 0.46-0.77), as was the eczema prevalence between 11 and 15 years in eHF-C (OR 0.42, 95% CI 0.23-0.79). No significant effects were found in the eHF-W group on any manifestation,nor was there an effect on sensitization with any formula.

CONCLUSION:

In high-risk children, early intervention using different hydrolyzed formulas has variable preventative effects on asthma, allergic rhinitis and eczema up to adolescence.

KEYWORDS:

15-year follow-up from birth; allergy prevention; double-blind; hydrolyzed infant formulas; nutritional intervention; randomized trial

PMID:
26465137
PMCID:
PMC4738469
DOI:
10.1111/all.12790
[Indexed for MEDLINE]
Free PMC Article

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