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Head Neck. 2016 Mar;38(3):E68-70. doi: 10.1002/hed.24165. Epub 2015 Oct 7.

Severe epistaxis due to aberrant vasculature in a patient with STAT-1 mutation.

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1
Department of Surgery, Section of Otolaryngology, Yale University School of Medicine, New Haven, Connecticut.

Abstract

BACKGROUND:

Signal transducer and activator 1 (STAT-1) mutations are rare and have been implicated in combined immunodeficiency, enhanced tumorigenesis, and vascular defects.

METHODS:

A 60-year-old woman with a novel STAT-1 mutation and resulting immunodeficiency, squamous cell carcinoma, and vascular disease presented with profuse epistaxis secondary to rupture of an aberrant artery that she developed in part because of this mutation. After unsuccessful posterior packing, embolization was initiated but subsequently aborted because of a bovine origin carotid artery and a history of multiple carotid dissections.

RESULTS:

After repeat posterior packing, hemostasis was achieved. No additional episodes of epistaxis occurred in the subsequent 13 months.

CONCLUSION:

Vascular anomalies can present challenges in epistaxis management. In patients with conditions known to cause vascular anomalies, it is critical to obtain vascular imaging before intervention.

KEYWORDS:

carcinoma; epistaxis; immunologic deficiency syndromes; signal transducer and activator 1 (STAT-1) transcription factor; squamous cell carcinoma of the head and neck; vascular diseases

PMID:
26445901
DOI:
10.1002/hed.24165
[Indexed for MEDLINE]
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