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Exp Cell Res. 2015 Dec 10;339(2):252-60. doi: 10.1016/j.yexcr.2015.09.015. Epub 2015 Sep 25.

Progress on the relationship between miR-125 family and tumorigenesis.

Author information

1
Dalian 24 High School, Dalian 116023, China.
2
Department of Neurosurgery, The Second Afiliated Hospital of Dalian Medical University, Dalian 116023, China.
3
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
4
Department of Ultrasonography, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China.
5
Department of Pathophysiology, Dalian Medical University, Dalian 116044, China.
6
Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
7
Department of Neurosurgery, The Second Afiliated Hospital of Dalian Medical University, Dalian 116023, China. Electronic address: weiminghai1765@163.com.

Abstract

miRNA-125 family, which is a highly conserved miRNA family throughout evolution, is consist of miRNA-125a-3p, miRNA-125a-5p, miRNA-125b-1 and miRNA-125b-2.The aberrant expression of miR-125 familyis tightly related to tumorigenesis and tumor development. The downstream targets of miRNA-125 include transcription factors like STAT3, cytokines like IL-6 and TGF-β, tumor suppressing protein p53, pro-apoptotic protein Bak1 and RNA binding protein HuR et al. Through regulating these downstream targets miR-125 family is involved in regulating tumorigenesis and tumor development. Nowadays, miR-125b have already became a putative and valuable biomarker for cancer diagnosis, treatment and prognosis. In this review, we mainly summarize the dual function of miRNA-125 family in suppression and promotion of cancer cells and further elaborate its regulatory mechanisms from four facets, proliferation, apoptosis, invasion or metastasis and immune response.

KEYWORDS:

MiR-125 family; Regulatory mechanism; Target genes; Tumor

PMID:
26407906
DOI:
10.1016/j.yexcr.2015.09.015
[Indexed for MEDLINE]
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