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Antimicrob Agents Chemother. 2015 Dec;59(12):7852-6. doi: 10.1128/AAC.01153-15. Epub 2015 Sep 21.

Artemether-Lumefantrine Exposure in HIV-Infected Nigerian Subjects on Nevirapine-Containing Antiretroviral Therapy.

Author information

1
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA sunil.parikh@yale.edu.
2
Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria Department of Clinical Pharmacology, University College Hospital, Ibadan, Nigeria.
3
Department of Clinical Pharmacy, University of California, San Francisco, California, USA.
4
Department of Clinical Pharmacology, University College Hospital, Ibadan, Nigeria.
5
Division of Infectious Diseases and Center for Global Health, Northwestern University, Chicago, Illinois, USA.
6
Translational Pharmacology Research Core, NYS Center of Excellence in Bioinformatics and Life Sciences, Department of Pharmacy Practice, University at Buffalo, Buffalo, New York, USA.
7
Department of Pediatrics, University of Ibadan, Ibadan, Nigeria.
8
Department of Obstetrics and Gynecology, University of Ibadan, Ibadan, Nigeria.
9
Department of Pharmacy Practice, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Abstract

Coadministration of nevirapine-based antiretroviral therapy (ART) and artemether-lumefantrine is reported to result in variable changes in lumefantrine exposure. We conducted an intensive pharmacokinetic study with 11 HIV-infected adults who were receiving artemether-lumefantrine plus nevirapine-based ART, and we compared the results with those for 16 HIV-negative adult historical controls. Exposure to artemether and lumefantrine was significantly lower and dihydroartemisinin exposure was unchanged in subjects receiving nevirapine-based ART, compared with controls. Nevirapine exposure was unchanged before and after artemether-lumefantrine administration.

PMID:
26392500
PMCID:
PMC4649208
DOI:
10.1128/AAC.01153-15
[Indexed for MEDLINE]
Free PMC Article
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