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Cell Stem Cell. 2015 Sep 3;17(3):249-50. doi: 10.1016/j.stem.2015.08.015.

Adaption by Rewiring Epigenetic Landscapes.

Author information

1
Department of Genetics and Yale Stem Cell Center, Yale University, New Haven, CT 06519, USA.
2
Department of Genetics and Yale Stem Cell Center, Yale University, New Haven, CT 06519, USA. Electronic address: andrew.xiao@yale.edu.

Abstract

Embryonic stem cells (ESCs) generally rely on repressive histone modifications to silence retrotransposons, rather than DNA methylation as in differentiated cells. In this issue of Cell Stem Cell, He et al. (2015) show that Daxx/Atrx repress transposons in ESCs devoid of 5mC, demonstrating dynamic reorganization of epigenetic networks and crosstalk between distinct repressive mechanisms to maintain transposon silencing.

PMID:
26340521
PMCID:
PMC4710369
DOI:
10.1016/j.stem.2015.08.015
[Indexed for MEDLINE]
Free PMC Article
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