Format

Send to

Choose Destination
See comment in PubMed Commons below
Structure. 2015 Sep 1;23(9):1561. doi: 10.1016/j.str.2015.08.001.

Cryo-EM: Spinning the Micelles Away.

Author information

1
Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address: satinder.k.singh@yale.edu.
2
Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address: fred.sigworth@yale.edu.

Abstract

Structural characterization of integral membrane proteins (MPs) demands that the samples be pure, monodisperse, and stable. Detergents are required to extract MPs from the lipid bilayer in which they reside and to stabilize them for downstream biophysical analyses. Some of the best MP-stabilizing detergents pose problems for cryo-EM studies, but in this issue of Structure, Hauer et al. (2015) now offer a solution called GraDeR.

PMID:
26331455
PMCID:
PMC4901521
DOI:
10.1016/j.str.2015.08.001
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center