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Maturitas. 2015 Nov;82(3):282-3. doi: 10.1016/j.maturitas.2015.07.018. Epub 2015 Aug 4.

Uterine stem cells--promise and possibilities.

Author information

1
Department of Obstetrics, Gynecology & Reproductive Sciences, Yale School of Medicine, CT, USA.

Abstract

A fraction of cells residing in the uterine endometrium exhibit functional pluripotent potential, allowing them to be classified as adult stem cells. While the physiological relevance of this cell population is mostly conjectural at this juncture, uterine endometrial stem cells (UESC's) may underline pathogenesis of certain common gynecological disorders, such as endometriosis and adenomyosis. The ease of access and harvesting of UESC's and the diverse differentiation potential of this cell population has identified the uterine endometrium as a valuable source of autologous stem cells that can be harnessed through judicious application of principals of regenerative medicine. This mini review offers a glimpse into the journey, and an introduction to the spectrum of disorders that UESC's have the potential of impacting.

KEYWORDS:

Endometrium; Stem cell; Uterine stem cell; Uterus

PMID:
26297687
DOI:
10.1016/j.maturitas.2015.07.018
[Indexed for MEDLINE]
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