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J Cell Biol. 2015 Aug 17;210(4):527-8. doi: 10.1083/jcb.201507052.

Paraspeckles: paragons of functional aggregation.

Author information

1
Yale University, New Haven, CT 06511.
2
Yale University, New Haven, CT 06511 karla.neugebauer@yale.edu.

Abstract

Low-complexity proteins undergo phase separation in vitro, forming hydrogels or liquid droplets. Whether these form in vivo, and under what conditions, is still unclear. In this issue, Hennig et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201504117) show that formation of the paraspeckle, a nuclear body that regulates gene expression, requires low-complexity prion-like domains (PLDs) within paraspeckle proteins. The same proteins were shown to form hydrogels, shedding light on the role of "functional aggregation" in nuclear substructure.

PMID:
26283795
PMCID:
PMC4539984
DOI:
10.1083/jcb.201507052
[Indexed for MEDLINE]
Free PMC Article

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