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Trends Immunol. 2015 Sep;36(9):556-64. doi: 10.1016/j.it.2015.07.002. Epub 2015 Aug 14.

Tissue instruction for migration and retention of TRM cells.

Author information

1
Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
2
Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: akiko.iwasaki@yale.edu.

Abstract

During infection, a subset of effector T cells seeds the lymphoid and non-lymphoid tissues and gives rise to tissue-resident memory T cells (TRM). Recent findings have provided insight into the molecular and cellular mechanisms underlying tissue instruction of TRM cell homing, as well as the programs involved in their retention and maintenance. We review these findings here, highlighting both common features and distinctions between CD4 TRM and CD8 TRM cells. In this context we examine the role of memory lymphocyte clusters (MLCs), and propose that the MLCs serve as an immediate response center consisting of TRM cells on standby, capable of detecting incoming pathogens and mounting robust local immune responses to contain and limit the spread of infectious agents.

PMID:
26282885
PMCID:
PMC4567393
DOI:
10.1016/j.it.2015.07.002
[Indexed for MEDLINE]
Free PMC Article
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