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Am J Surg. 2015 Nov;210(5):886-90. doi: 10.1016/j.amjsurg.2015.05.018. Epub 2015 Jul 18.

Does three-dimensional intraoperative specimen imaging reduce the need for re-excision in breast cancer patients? A prospective cohort study.

Author information

1
Department of Surgery, Yale University School of Medicine, 20 York Street, New Haven, CT 06510, USA. Electronic address: anees.chagpar@yale.edu.
2
Department of Surgery, Yale University School of Medicine, 20 York Street, New Haven, CT 06510, USA.

Abstract

BACKGROUND:

Standard two-dimensional (2D) specimen radiography may guide intraoperative re-excision of margins in patients undergoing breast conserving surgery. We sought to determine the impact of three-dimensional (3D) specimen imaging in further reducing positive margin rates.

METHODS:

A prospective study of 100 patients in which both 2D and 3D specimen radiographies were performed. The impact of orthogonal view on intraoperative surgical management and final margins was assessed.

RESULTS:

Ten patients had no residual tumor; therefore, 90 patients formed the cohort of interest. Of them, 21 patients (23.3%) had ductal carcinoma in situ; 18 (20.0%) had invasive cancer; and 51 (56.7%) had both. Median tumor size was 1.7 cm (range, .2 to 8.1 cm). On the basis of 2D imaging, surgeons stated they would take more tissue in 26 patients (28.9%). Three-dimensional imaging changed management in 4 patients (6.3%). One of these patients would have had positive margins if the intraoperative resection done on the basis of the 3D imaging would have been omitted.

CONCLUSIONS:

Three-dimensional specimen imaging results in further intraoperative re-excision in 6.3% of patients and may reduce re-excision rates in 2.2%.

KEYWORDS:

Breast conservation; Margins; Specimen radiography; Surgery

PMID:
26255230
DOI:
10.1016/j.amjsurg.2015.05.018
[Indexed for MEDLINE]

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