Format

Send to

Choose Destination
See comment in PubMed Commons below
Cold Spring Harb Perspect Biol. 2015 Aug 3;7(8):a018978. doi: 10.1101/cshperspect.a018978.

Functional differentiation of adult-born neurons along the septotemporal axis of the dentate gyrus.

Author information

1
Department of Psychiatry, Columbia University, New York, New York 10027 Division of Integrative Neuroscience, New York State Psychiatric Institute, New York, New York 10032.
2
Center for Regenerative Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114 Harvard Stem Cell Institute and Harvard Medical School, Boston, Massachusetts 02115.
3
Department of Psychiatry, Yale University, New Haven, Connecticut 06520 Department of Neurobiology, Yale University, New Haven, Connecticut 06520.
4
Department of Psychiatry, Columbia University, New York, New York 10027 Division of Integrative Neuroscience, New York State Psychiatric Institute, New York, New York 10032 Department of Neuroscience, Columbia University, New York, New York 10027 Department of Pharmacology, Columbia University, New York, New York 10027.

Abstract

Over the past several decades, the proliferation and integration of adult-born neurons into existing hippocampal circuitry has been implicated in a wide range of behaviors, including novelty recognition, pattern separation, spatial learning, anxiety behaviors, and antidepressant response. In this review, we suggest that the diversity in behavioral requirements for new neurons may be partly caused by separate functional roles of individual neurogenic niches. Growing evidence shows that the hippocampal formation can be compartmentalized not only along the classic trisynaptic circuit, but also along a longitudinal septotemporal axis. We suggest that subpopulations of hippocampal adult-born neurons may be specialized for distinct mnemonic- or mood-related behavioral tasks. We will examine the literature supporting a functional and anatomical dissociation of the hippocampus along the longitudinal axis and discuss techniques to functionally dissect the roles of adult-born hippocampal neurons in these distinct subregions.

PMID:
26238355
DOI:
10.1101/cshperspect.a018978
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center