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J Neurol Surg B Skull Base. 2015 Jun;76(3):208-13. doi: 10.1055/s-0034-1543995. Epub 2015 Jan 5.

Predictors of Survival in Sinonasal Adenocarcinoma.

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Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, United States.
Department of Surgery, Duke University School of Medicine, Durham, North Carolina, United States.
Department of Surgery, Duke University School of Medicine, Durham, North Carolina, United States ; Endocrine Neoplasia Diseases Group, Duke Clinical Research Institute, Duke University, Durham, North Carolina, United States.
Section of Otolaryngology, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, United States.


Objectives To identify factors associated with disease-specific survival (DSS) in intestinal and nonintestinal sinonasal adenocarcinoma. Design Retrospective review. Setting Surveillance Epidemiology and End Results database. Participants Adult patients with sinonasal adenocarcinoma. Main Outcome Measures DSS. Results We identified 325 patients; of these, 300 had the nonintestinal type and 25 had intestinal type histologies. The 5-year DSS rates for patients who had no treatment, radiation (RT), surgery, and surgery and postoperative RT were 42.5, 46.1, 85.6, and 72.6%, respectively (log-rank test; p < 0.001). Black race, age ≥ 75 years, paranasal sinus involvement, and high grade were independently associated with decreased DSS. Compared with RT, surgery (hazard ratio [HR]: 0.34; 95% confidence interval [CI]: 0.15-0.77), and adjuvant RT (HR: 0.47; 95% CI, 0.26-0.86) were associated with improved DSS. Conclusions There is no difference in prognosis between intestinal and nonintestinal subtypes of sinonasal adenocarcinoma. Treatment with surgery alone or adjuvant RT is associated with a more favorable prognosis.


adenocarcinoma; intestinal type; nonintestinal type; sinonasal; survival

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