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Radiology. 2015 Aug;276(2):315-7. doi: 10.1148/radiol.2015150451.

Science to Practice: The Changing Face of Local Tumor Therapies-Do We Have to Think Systemically When Treating Cancer Locally?

Author information

1
Department of Diagnostic and Interventional Radiology Charité Universitätsmedizin Berlin Berlin, Germany.
2
Department of Diagnostic Radiology and Imaging Sciences Yale University School of Medicine 421 Temple St New Haven, CT 06520-8224.

Abstract

In this issue, Rozenblum et al ( 1 ) were able to demonstrate that radiofrequency (RF) ablation-induced liver regeneration promotes "off-target" tumorigenesis in a MDR2 knock-out mouse model of hepatocellular carcinoma (HCC) in the setting of chronic liver inflammation. In addition, the authors demonstrated that blocking liver regeneration with a c-met inhibitor might attenuate or eliminate potential tumorigenic effects. These results provide the rationale for combined therapeutic approaches of RF ablation followed by a systemic application of immunomodulatory drugs.

PMID:
26203703
PMCID:
PMC4520212
DOI:
10.1148/radiol.2015150451
[Indexed for MEDLINE]
Free PMC Article
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