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Behav Brain Res. 2015 Oct 15;293:241-51. doi: 10.1016/j.bbr.2015.06.043. Epub 2015 Jul 17.

A novel relationship for schizophrenia, bipolar and major depressive disorder Part 7: A hint from chromosome 7 high density association screen.

Author information

1
Department of Medical Genetics, Institute of Basic Medicine, Shandong Academy of Medical Sciences, 18877 Jingshi Road, Jinan 250062, Shandong, People's Republic of China.
2
CapitalBio corporation, 18 Life Science Parkway, Changping District, Beijing 102206, People's Republic of China.
3
Department of Medical Genetics, Institute of Basic Medicine, Shandong Academy of Medical Sciences, 18877 Jingshi Road, Jinan 250062, Shandong, People's Republic of China. Electronic address: chengang560515@163.com.

Abstract

Convergent evidence from genetics, symptology and psychopharmacology imply that there are intrinsic connection between schizophrenia (SCZ), bipolar disorder (BPD) and major depressive disorder (MDD). Also, any two or even three of these disorders could co-existe in some families. A total of 47,144 single nucleotide polymorphism (SNPs) on chromosome 7 were genotyped by Affymetrix Genome-Wide Human SNP array 6.0 on 119 SCZ, 253 BPD (type-I), 177 MDD, and 1000 controls. Associated SNP loci were comprehensively revealed and outstanding susceptibility genes were identified including CNTNAP2. a neurexin family gene. Unexpectedly, flanking genes for up to 94.74 % of of the associated SNPs were replicated (P≤9.9 E-8) in an enlarged cohort of 986 SCZ patients. Considering other convergent evidence, our results further implicate that BPD and MDD are subtypes of SCZ.

KEYWORDS:

Association; Bipolar disorder; Gene; Major depressive disorder; Schizophrenia; Subtype

PMID:
26192912
DOI:
10.1016/j.bbr.2015.06.043
[Indexed for MEDLINE]

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