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Curr Opin Cell Biol. 2015 Oct;36:41-7. doi: 10.1016/j.ceb.2015.06.009. Epub 2015 Jul 17.

Regulation of integrin-mediated adhesions.

Author information

1
Department of Pharmacology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06520, USA.
2
Department of Pharmacology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06520, USA; Department of Cell Biology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06520, USA. Electronic address: david.calderwood@yale.edu.

Abstract

Integrins are heterodimeric transmembrane adhesion receptors that couple the actin cytoskeleton to the extracellular environment and bidirectionally relay signals across the cell membrane. These processes are critical for cell attachment, migration, differentiation, and survival, and therefore play essential roles in metazoan development, physiology, and pathology. Integrin-mediated adhesions are regulated by diverse factors, including the conformation-specific affinities of integrin receptors for their extracellular ligands, the clustering of integrins and their intracellular binding partners into discrete adhesive structures, mechanical forces exerted on the adhesion, and the intracellular trafficking of integrins themselves. Recent advances shed light onto how the interaction of specific intracellular proteins with the short cytoplasmic tails of integrins controls each of these activities.

PMID:
26189062
PMCID:
PMC4639423
DOI:
10.1016/j.ceb.2015.06.009
[Indexed for MEDLINE]
Free PMC Article

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