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Mol Pharmacol. 2015 Sep;88(3):534-5. doi: 10.1124/mol.115.100750. Epub 2015 Jul 10.

Exploring the Biology of G Protein-Coupled Receptors from In Vitro to In Vivo.

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The Scripps Research Institute, Jupiter, Florida (L.M.B.), University of Würzburg, Würzburg, Germany (M.J.L.); Yale University, New Haven, Connecticut (M.N.N.); Washington University Medical School, St. Louis, Missouri (P.H.T.); and VU University Amsterdam, Amsterdam, The Netherlands (M.J.S.).


In August 2014, an international group of researchers gathered for 5 days at the Lorentz Center in Leiden, The Netherlands, to explore the technical and conceptual issues associated with the analysis of G protein-coupled receptor functions utilizing information from crystal structure models to the use of model organisms. This collection of review articles evolved from the 5-day meeting, with brief presentations and structured discussion periods that were designed to identify key questions remaining in understanding G protein-coupled receptor function and to propose novel strategies by integrating scientific disciplines to guide future research.

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