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Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8499-504. doi: 10.1073/pnas.1502513112. Epub 2015 Jun 22.

Synaptic clusters function as odor operators in the olfactory bulb.

Author information

1
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520; Institute of Biophysics, National Research Council, 90146 Palermo, Italy; michele.migliore@cnr.it.
2
Institute of Biophysics, National Research Council, 90146 Palermo, Italy; Department of Mathematics "Federigo Enriques," University of Milan, 20122 Milan, Italy;
3
Department of Mathematics and Applications "R. Caccioppoli," University of Naples Federico II, 80126 Naples, Italy.
4
Institute of Biophysics, National Research Council, 90146 Palermo, Italy;
5
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520;

Abstract

How the olfactory bulb organizes and processes odor inputs through fundamental operations of its microcircuits is largely unknown. To gain new insight we focus on odor-activated synaptic clusters related to individual glomeruli, which we call glomerular units. Using a 3D model of mitral and granule cell interactions supported by experimental findings, combined with a matrix-based representation of glomerular operations, we identify the mechanisms for forming one or more glomerular units in response to a given odor, how and to what extent the glomerular units interfere or interact with each other during learning, their computational role within the olfactory bulb microcircuit, and how their actions can be formalized into a theoretical framework in which the olfactory bulb can be considered to contain "odor operators" unique to each individual. The results provide new and specific theoretical and experimentally testable predictions.

KEYWORDS:

granule cells; mitral cells; network self-organization; odor coding; olfactory bulb system

PMID:
26100895
PMCID:
PMC4500266
DOI:
10.1073/pnas.1502513112
[Indexed for MEDLINE]
Free PMC Article
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