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Trends Endocrinol Metab. 2015 Jul;26(7):337-8. doi: 10.1016/j.tem.2015.05.011. Epub 2015 Jun 6.

SGLT-2 inhibition and glucagon: Cause for alarm?

Author information

1
Departments of Internal Medicine (Endocrinology) and Cellular & Molecular Physiology, Yale School of Medicine, 300 Cedar St. PO 208020, New Haven CT 06520. Electronic address: Richard.Kibbey@yale.edu.

Abstract

Recent studies raised the alarm that the inhibition of sodium-coupled glucose transporter type-2 in humans increases endogenous glucose production rates by an unclear mechanism. Surprisingly, a potential explanation may be linked directly to the alpha-cell. Is this a mechanistic spoiler or an added benefit?

KEYWORDS:

HNF4alpha; SGLT-2 inhibitors; alpha-cell; glucagon; glucose production

PMID:
26059706
PMCID:
PMC4490128
DOI:
10.1016/j.tem.2015.05.011
[Indexed for MEDLINE]
Free PMC Article

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