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Cell Mol Life Sci. 2015 Sep;72(18):3441-3455. doi: 10.1007/s00018-015-1935-x. Epub 2015 May 29.

Biogenesis of endosome-derived transport carriers.

Author information

1
Department of Cell Biology, Yale School of Medicine, SHM C425B, 333 Cedar Street, New Haven, CT 06520, USA.
#
Contributed equally

Abstract

Sorting of macromolecules within the endosomal system is vital for physiological control of nutrient homeostasis, cell motility, and proteostasis. Trafficking routes that export macromolecules from the endosome via vesicle and tubule transport carriers constitute plasma membrane recycling and retrograde endosome-to-Golgi pathways. Proteins of the sorting nexin family have been discovered to function at nearly every step of endosomal transport carrier biogenesis and it is becoming increasingly clear that they form the core machineries of cargo-specific transport pathways that are closely integrated with cellular physiology. Here, we summarize recent progress in elucidating the pathways that mediate the biogenesis of endosome-derived transport carriers.

PMID:
26022064
PMCID:
PMC4890637
DOI:
10.1007/s00018-015-1935-x
[Indexed for MEDLINE]
Free PMC Article

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