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ACS Biomater Sci Eng. 2015 Feb 9;1(2):64-78. Epub 2015 Jan 13.

Nanotherapy for Cancer: Targeting and Multifunctionality in the Future of Cancer Therapies.

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Department of Biomedical Engineering, Yale University , 55 Prospect Street, MEC 414, New Haven, Connecticut 06511, United States.


Cancer continues to be a prevalent and lethal disease, despite advances in tumor biology research and chemotherapy development. Major obstacles in cancer treatment arise from tumor heterogeneity, drug resistance, and systemic toxicities. Nanoscale delivery systems, or nanotherapies, are increasing in importance as vehicles for antineoplastic agents because of their potential for targeting and multifunctionality. We discuss the current field of cancer therapy and potential strategies for addressing obstacles in cancer treatment with nanotherapies. Specifically, we review the strategies for rationally designing nanoparticles for targeted, multimodal delivery of therapeutic agents.


cancer therapy; drug delivery; gene delivery; nanoparticle

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