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Ann Oncol. 2015 Aug;26(8):1776-83. doi: 10.1093/annonc/mdv236. Epub 2015 May 14.

Vitamin D and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Case-Control Consortium.

Author information

1
Division of Population Health, QIMR Berghofer Medical Research Institute, Herston Centre for Research Excellence in Sun and Health, Queensland University of Technology, Kelvin Grove, Australia.
2
Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, USA.
3
Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy.
4
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis.
5
Department of Health Sciences Research, Mayo Clinic, Rochester, USA.
6
Prevention and Cancer Control, Cancer Care Ontario, Toronto Dalla Lana School of Public Health, University of Toronto, Toronto.
7
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto Department of Surgery, University of Toronto, Toronto, Canada.
8
Division of Population Health, QIMR Berghofer Medical Research Institute, Herston.
9
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
10
Truven Health Analytics, Durham.
11
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, USA.
12
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.
13
National Institute for Public Health and the Environment, Bilthoven Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.
14
Department of Epidemiology, The Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
15
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, USA.
16
Division of Population Health, QIMR Berghofer Medical Research Institute, Herston Centre for Research Excellence in Sun and Health, Queensland University of Technology, Kelvin Grove, Australia rachel.neale@qimrberghofer.edu.au.

Abstract

BACKGROUND:

The potential role of vitamin D in the aetiology of pancreatic cancer is unclear, with recent studies suggesting both positive and negative associations.

PATIENTS AND METHODS:

We used data from nine case-control studies from the International Pancreatic Cancer Case-Control Consortium (PanC4) to examine associations between pancreatic cancer risk and dietary vitamin D intake. Study-specific odds ratios (ORs) were estimated using multivariable logistic regression, and ORs were then pooled using a random-effects model. From a subset of four studies, we also calculated pooled estimates of association for supplementary and total vitamin D intake.

RESULTS:

Risk of pancreatic cancer increased with dietary intake of vitamin D [per 100 international units (IU)/day: OR = 1.13, 95% confidence interval (CI) 1.07-1.19, P = 7.4 × 10(-6), P-heterogeneity = 0.52; ≥230 versus <110 IU/day: OR = 1.31, 95% CI 1.10-1.55, P = 2.4 × 10(-3), P-heterogeneity = 0.81], with the association possibly stronger in people with low retinol/vitamin A intake.

CONCLUSION:

Increased risk of pancreatic cancer was observed with higher levels of dietary vitamin D intake. Additional studies are required to determine whether or not our finding has a causal basis.

KEYWORDS:

case–control studies; pancreatic cancer; pooled analysis; vitamin D

PMID:
25977560
PMCID:
PMC4511221
DOI:
10.1093/annonc/mdv236
[Indexed for MEDLINE]
Free PMC Article

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