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Am J Physiol Lung Cell Mol Physiol. 2015 Jul 1;309(1):L1-10. doi: 10.1152/ajplung.00339.2014. Epub 2015 May 8.

Role of macrophage migration inhibitory factor in age-related lung disease.

Author information

1
Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut; and.
2
Section of Rheumatology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
3
Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut; and patty.lee@yale.edu.

Abstract

The prevalence of many common respiratory disorders, including pneumonia, chronic obstructive lung disease, pulmonary fibrosis, and lung cancer, increases with age. Little is known of the host factors that may predispose individuals to such diseases. Macrophage migration inhibitory factor (MIF) is a potent upstream regulator of the immune system. MIF is encoded by variant alleles that occur commonly in the population. In addition to its role as a proinflammatory cytokine, a growing body of literature demonstrates that MIF influences diverse molecular processes important for the maintenance of cellular homeostasis and may influence the incidence or clinical manifestations of a variety of chronic lung diseases. This review highlights the biological properties of MIF and its implication in age-related lung disease.

KEYWORDS:

MIF; innate immunity; lung

PMID:
25957294
PMCID:
PMC4491511
DOI:
10.1152/ajplung.00339.2014
[Indexed for MEDLINE]
Free PMC Article

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