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Circ Res. 2015 May 8;116(10):1712-24. doi: 10.1161/CIRCRESAHA.116.302953.

Molecular controls of arterial morphogenesis.

Author information

1
From the Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine (M.S., A.E.) and Departments of Cell Biology (M.S.) and Molecular Physiology (A.E.), Yale University School of Medicine, New Haven, CT. michael.simons@yale.edu anne.eichmann@yale.edu.

Abstract

Formation of arterial vasculature, here termed arteriogenesis, is a central process in embryonic vascular development as well as in adult tissues. Although the process of capillary formation, angiogenesis, is relatively well understood, much remains to be learned about arteriogenesis. Recent discoveries point to the key role played by vascular endothelial growth factor receptor 2 in control of this process and to newly identified control circuits that dramatically influence its activity. The latter can present particularly attractive targets for a new class of therapeutic agents capable of activation of this signaling cascade in a ligand-independent manner, thereby promoting arteriogenesis in diseased tissues.

KEYWORDS:

angiogenesis factor; arteries; arteriogenesis; vascular endothelial growth factor A

PMID:
25953926
PMCID:
PMC4509635
DOI:
10.1161/CIRCRESAHA.116.302953
[Indexed for MEDLINE]
Free PMC Article

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