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Org Lett. 2015 May 15;17(10):2400-3. doi: 10.1021/acs.orglett.5b00910. Epub 2015 May 6.

Cobalt(III)-Catalyzed C-H Bond Amidation with Isocyanates.

Author information

1
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.

Abstract

The first examples of cobalt(III)-catalyzed C-H bond addition to isocyanates are described, providing a convergent strategy for arene and heteroarene amidation. Using a robust air- and moisture-stable catalyst, this transformation demonstrates a broad isocyanate scope and good functional-group compatibility and has been performed on gram scale.

PMID:
25945401
PMCID:
PMC4460580
DOI:
10.1021/acs.orglett.5b00910
[Indexed for MEDLINE]
Free PMC Article

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