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Curr Opin Struct Biol. 2015 Apr;31:106-14. doi: 10.1016/j.sbi.2015.04.004. Epub 2015 May 16.

HIV suppression by host restriction factors and viral immune evasion.

Author information

1
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
2
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA. Electronic address: yong.xiong@yale.edu.

Abstract

Antiviral restriction factors are an integral part of the host innate immune system that protects cells from viral pathogens, such as human immunodeficiency virus (HIV). Studies of the interactions between restriction factors and HIV have greatly advanced our understanding of both the viral life cycle and basic cell biology, as well as provided new opportunities for therapeutic intervention of viral infection. Here we review the recent developments towards establishing the structural and biochemical bases of HIV inhibition by, and viral countermeasures of, the restriction factors TRIM5, MxB, APOBEC3, SAMHD1, and BST2/tetherin.

PMID:
25939065
PMCID:
PMC4476947
DOI:
10.1016/j.sbi.2015.04.004
[Indexed for MEDLINE]
Free PMC Article

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