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Antimicrob Agents Chemother. 2015 Jul;59(7):4331-5. doi: 10.1128/AAC.00127-15. Epub 2015 Apr 27.

First description of azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation in France.

Author information

1
Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155-IICiMed, Faculté de Pharmacie, Nantes, France Laboratoire de Parasitologie-Mycologie, Institut de Biologie, CHU de Nantes, Nantes, France.
2
EA3800, Laboratoire de Parasitologie-Mycologie, Université de Rouen et CHU de Rouen, Rouen, France.
3
Department of Pneumology, Cystic Fibrosis Center, Rouen University Hospital, Rouen, France.
4
Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
5
Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
6
Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155-IICiMed, Faculté de Pharmacie, Nantes, France Laboratoire de Parasitologie-Mycologie, Institut de Biologie, CHU de Nantes, Nantes, France patrice.le-pape@univ-nantes.fr.

Abstract

Azole resistance in Aspergillus fumigatus is an emerging public health concern. Recently, a novel fungicide-driven mutation in the cyp51A gene and its promoter, TR46/Y121F/T289A, leading to high-level resistance to voriconazole has been identified in The Netherlands, Belgium, Germany, Denmark, Tanzania, and India in both clinical and environmental samples. Here we report the first description of A. fumigatus carrying this mutation in France, in a cystic fibrosis patient, underlining the need for extensive monitoring of Aspergillus resistance.

PMID:
25918139
PMCID:
PMC4468656
DOI:
10.1128/AAC.00127-15
[Indexed for MEDLINE]
Free PMC Article

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