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Reprod Biomed Online. 2015 Jun;30(6):581-92. doi: 10.1016/j.rbmo.2015.03.002. Epub 2015 Mar 16.

How to define, diagnose and treat poor responders? Responses from a worldwide survey of IVF clinics.

Author information

1
Yale University Fertility Center, New Haven, Connecticut, USA. Electronic address: pasquale.patrizio@yale.edu.
2
Centre for Reproductive Medicine, Vrije University Brussels, Belgium.
3
Department of Gynecology, Division of Gynecology and Reproductive Medicine, Humanitas Research Hospital Fertility Center, Rozzano, Milan 20084, Italy.
4
Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology and Infertility, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
5
Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
6
The Women's Clinic, Hong Kong.
7
Department of Obstetrics and Gynaecology, Kaplan Medical Center, Rehovot, Israel; Hadassah Medical School, Jerusalem, Israel.

Abstract

Poor responders represent a significant percentage of couples treated in IVF units (10-24%), but the standard definition of poor responders remains uncertain and consequently optimal treatment options remain subjective and not evidence-based. In an attempt to provide uniformity on the definition, diagnosis and treatment of poor responders, a worldwide survey was conducted asking IVF professionals a set of questions on this complex topic. The survey was posted on www.IVF-worldwide.com, the largest and most comprehensive IVF-focused website for physicians and embryologists. A total of 196 centres replied, forming a panel of IVF units with a median of 400 cycles per year. The present study shows that the definition of poor responders is still subjective, and many practices do not use evidence-based treatment for this category of patients. Our hope is that by leveraging the great potential of the internet, future studies may provide immediate large-scale sampling to standardize both poor responder definition and treatment options.

KEYWORDS:

IVF; decreased ovarian function; management; ovarian stimulation; poor responder; survey

PMID:
25892496
DOI:
10.1016/j.rbmo.2015.03.002
[Indexed for MEDLINE]

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