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J Am Med Dir Assoc. 2015 Aug 1;16(8):682-9. doi: 10.1016/j.jamda.2015.03.010. Epub 2015 Apr 11.

Associations Between Ankle-Brachial Index and Cognitive Function: Results From the Lifestyle Interventions and Independence for Elders Trial.

Collaborators (161)

Pahor M, Guralnik JM, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu CJ, Miller ME, Espeland MA, Ambrosius WT, Applegate W, Beavers DP, Byington RP, Cook D, Furberg CD, Harvin LN, Henkin L, Hepler J, Hsu FC, Lovato L, Roberson W, Rushing J, Rushing S, Stowe CL, Walkup MP, Hire D, Rejeski W, Katula JA, Brubaker PH, Mihalko SL, Jennings JM, Hadley EC, Romashkan S, Bonds DE, Patel KV, McDermott MM, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church TS, Blair SN, Myers VH, Monce R, Britt NE, Harris MN, McGucken AP, Rodarte R, Millet HK, Tudor-Locke C, Butitta BP, Donatto SG, Cocreham SH, King AC, Castro CM, Haskell WL, Stafford RS, Pruitt LA, Yank V, Berra K, Bell C, Thiessen RM, Youngman KP, Virgen SB, Maldonado E, Tarin KN, Klaftenegger H, Prosak CA, Campero I, Garcia DM, Soto J, Chio L, Hoskins D, Fielding RA, Nelson ME, Folta SC, Phillips EM, Liu CK, McDavitt EC, Reid KF, Kim WS, Beard VE, Manini TM, Pahor M, Anton SD, Nayfield S, Buford TW, Marsiske M, Sandesara BD, Knaggs JD, Lorow MS, Marena WC, Korytov I, Morris HL, Fitch M, Singletary FF, Causer J, Radcliff KA, Newman AB, Studenski SA, Goodpaster BH, Glynn NW, Lopez O, Nadkarni NK, Williams K, Newman MA, Grove G, Bonk JT, Rush J, Kost P, Ives DG, Kritchevsky SB, Marsh AP, Brinkley TE, Demons JS, Sink KM, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill TM, Axtell RS, Kashaf SS, de Rekeneire N, McGloin JM, Wu KC, Shepard DM, Fennelly B, Iannone LP, Mautner R, Barnett TS, Halpin SN, Brennan MJ, Bugaj JA, Zenoni MA, Mignosa BM, Williamson J, Sink KM, Hendrie HC, Rapp SR, Verghese J, Woolard N, Espeland M, Jennings J, Pepine CJ, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp GL, Flynn GM, Gill TM, Hankinson JL, Vaz Fragoso CA, Groessl EJ, Kaplan RM.

Author information

1
Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC. Electronic address: mespelan@wakehealth.edu.
2
Healthy Aging Research Program, University of Pittsburgh, Pittsburgh, PA.
3
J. Paul Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC.
4
Department of Medicine, Yale School of Medicine, New Haven, CT.
5
Department of Health and Research Policy and Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA.
6
Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
7
Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD.
8
Department of Health and Exercise Sciences, Wake Forest University, Winston-Salem, NC.
9
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA.
10
Department of Aging and Geriatric Research, University of Florida, Gainesville, FL.
11
Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
12
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.

Abstract

OBJECTIVE:

The objective of this study was to evaluate cross-sectional and longitudinal associations between ankle-brachial index (ABI) and indicators of cognitive function.

DESIGN:

Randomized clinical trial (Lifestyle Interventions and Independence for Elders Trial).

SETTING:

Eight US academic centers.

PARTICIPANTS:

A total of 1601 adults ages 70-89 years, sedentary, without dementia, and with functional limitations.

MEASUREMENTS:

Baseline ABI and interviewer- and computer-administered cognitive function assessments were obtained. These assessments were used to compare a physical activity intervention with a health education control. Cognitive function was reassessed 24 months later (interviewer-administered) and 18 or 30 months later (computer-administered) and central adjudication was used to classify individuals as having mild cognitive impairment, probable dementia, or neither.

RESULTS:

Lower ABI had a modest independent association with poorer cognitive functioning at baseline (partial r = 0.09; P < .001). Although lower baseline ABI was not associated with overall changes in cognitive function test scores, it was associated with higher odds for 2-year progression to a composite of either mild cognitive impairment or probable dementia (odds ratio 2.60 per unit lower ABI; 95% confidence interval 1.06-6.37). Across 2 years, changes in ABI were not associated with changes in cognitive function.

CONCLUSION:

In an older cohort sedentary individuals with dementia and with functional limitations, lower baseline ABI was independently correlated with cognitive function and associated with greater 2-year risk for progression to mild cognitive impairment or probable dementia.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01072500.

KEYWORDS:

Cognitive function; ankle-brachial index; dementia; peripheral artery disease

PMID:
25869993
PMCID:
PMC4516564
DOI:
10.1016/j.jamda.2015.03.010
[Indexed for MEDLINE]
Free PMC Article

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