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Cell Host Microbe. 2015 Apr 8;17(4):425-7. doi: 10.1016/j.chom.2015.03.013.

Two tales (tails) of SAMHD1 destruction by Vpx.

Author information

1
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
2
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. Electronic address: yong.xiong@yale.edu.

Abstract

The lentivirus protein Vpx/Vpr recognizes the host restriction factor SAMHD1 at either its N- or C-terminal tail and targets it for destruction by the cellular protein degradation machinery. In this issue of Cell Host & Microbe, Schwefel et al. (2015) report the structural basis of SAMHD1 N-terminal targeting by Vpx.

PMID:
25856752
DOI:
10.1016/j.chom.2015.03.013
[Indexed for MEDLINE]
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