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Actas Esp Psiquiatr. 2015 Mar-Apr;43(2):35-41. Epub 2015 Mar 1.

Detection of anti-streptococcal, antienolase, and anti-neural antibodies in subjects with early-onset psychiatric disorders.

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Universidad Autónoma de la Ciudad de México (UACM) Grupo Medico Carracci Servicios de Atención Psiquiátrica (SAP) Secretaria de Salud.
Centro de Neurociencias de Cuba.
Universidad Autónoma de la Ciudad de México (UACM) Servicios de Atención Psiquiátrica (SAP) Secretaria de Salud.
Universidad Autónoma de la Ciudad de México (UACM).
Clínica del Adolescente, La Habana, Cuba.
Servicios de Atención Psiquiátrica (SAP) Secretaria de Salud.
Grupo Medico Carracci.
Instituto Nacional de Neurología (INNMVS).



Infection with group A Streptococcus (StrepA) can cause post-infectious sequelae, including a spectrum of childhood-onset obsessive-compulsive (OCD) and tic disorders with autoimmune origin (PANDAS, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections). Until now, no single immunological test has been designed that unequivocally diagnoses these disorders. In this study, we assessed the detection of serum antibodies against human brain enolase (AE), neural tissue (AN) and Streptococcus (AS) as a laboratory tool for the diagnosis of early-onset psychiatric disorders.


Serum antibodies against human brain enolase, total brain proteins, and total proteins from StrepA were detected by ELISA in 37 patients with a presumptive diagnosis of PANDAS and in 12 healthy subjects from Mexico and Cuba.


The antibody titers against human brain enolase (AE) and Streptococcal proteins (AS) were higher in patients than in control subjects (t-student, tAE=-2.17, P=0.035; tAS=-2.68, P=0.01, n=12 and 37/group, df=47, significance level 0.05), while the neural antibody titers did not differ between the two groups (P(t)=0.05). The number of subjects (titers> meancontrol + CI95) with simultaneous seropositivity to all three antibodies was higher in the patient group (51.4%) than in the control group (8.3%) group (X2=5.27, P=0.022, df=1, n=49).


The simultaneous detection of all three of these antibodies could provide valuable information for the etiologic diagnosis of individuals with early-onset obsessive-compulsive disorders associated with streptococcal infection and, consequently, for prescribing suitable therapy.

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