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Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):779-782. doi: 10.1161/ATVBAHA.114.304525. Epub 2015 Feb 19.

Endothelial glucocorticoid receptor suppresses atherogenesis--brief report.

Author information

1
Department of Pediatrics, Yale University School of Medicine, New Haven, CT.
2
Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT.
3
Department of Internal Medicine (Cardiology), Yale University School of Medicine, New Haven, CT.
4
Integrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT.
5
Department of Pharmacology, Yale University School of Medicine, New Haven, CT.
#
Contributed equally

Abstract

OBJECTIVE:

The purpose of this study was to determine the role of the endothelial glucocorticoid receptor in the pathogenesis of atherosclerosis.

APPROACH AND RESULTS:

Control mice and mice lacking the endothelial glucocorticoid receptor were bred onto an Apoe knockout background and subjected to high-fat diet feeding for 12 weeks. Assessment of body weight and total cholesterol and triglycerides before and after the diet revealed no differences between the 2 groups of mice. However, mice lacking the endothelial glucocorticoid receptor developed more severe atherosclerotic lesions in the aorta, brachiocephalic artery, and aortic sinus, as well as a heightened inflammatory milieu as evidenced by increased macrophage recruitment in the lesions.

CONCLUSIONS:

These data suggest that the endothelial glucocorticoid receptor is important for tonic inhibition of inflammation and limitation of atherosclerosis progression in this model.

KEYWORDS:

atherosclerosis; endothelium; glucocorticoid receptor

PMID:
25810297
PMCID:
PMC4375730
DOI:
10.1161/ATVBAHA.114.304525
[Indexed for MEDLINE]
Free PMC Article

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