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Biostatistics. 2015 Jul;16(3):427-40. doi: 10.1093/biostatistics/kxv006. Epub 2015 Mar 19.

Markov counting models for correlated binary responses.

Author information

1
Yale School of Public Health, Biostatistics, PO Box 208034, New Haven, CT 06510, USA forrest.crawford@yale.edu.
2
Yale School of Public Health, Biostatistics, PO Box 208034, New Haven, CT 06510, USA.

Abstract

We propose a class of continuous-time Markov counting processes for analyzing correlated binary data and establish a correspondence between these models and sums of exchangeable Bernoulli random variables. Our approach generalizes many previous models for correlated outcomes, admits easily interpretable parameterizations, allows different cluster sizes, and incorporates ascertainment bias in a natural way. We demonstrate several new models for dependent outcomes and provide algorithms for computing maximum likelihood estimates. We show how to incorporate cluster-specific covariates in a regression setting and demonstrate improved fits to well-known datasets from familial disease epidemiology and developmental toxicology.

KEYWORDS:

Bernoulli trials; Developmental toxicity; Familial disease; Markov process; Teratology

PMID:
25792624
PMCID:
PMC5963474
DOI:
10.1093/biostatistics/kxv006
[Indexed for MEDLINE]
Free PMC Article

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