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Biopolymers. 2015 Jul;104(4):334-50. doi: 10.1002/bip.22639.

Protein design: Past, present, and future.

Author information

1
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT.
2
Department of Chemistry, Yale University, New Haven, CT.
3
Integrated Graduate Program in Physical and Engineering Biology, Yale University, New Haven, CT.
4
Department of Physics, Yale University, New Haven, CT.
5
Department of Mechanical Engineering and Materials Science, Yale University, New Haven, CT.
6
Department of Applied Physics, Yale University, New Haven, CT.

Abstract

Building on the pioneering work of Ho and DeGrado (J Am Chem Soc 1987, 109, 6751-6758) in the late 1980s, protein design approaches have revealed many fundamental features of protein structure and stability. We are now in the era that the early work presaged - the design of new proteins with practical applications and uses. Here we briefly survey some past milestones in protein design, in addition to highlighting recent progress and future aspirations.

KEYWORDS:

computation; nanotechnology; protein design; review

PMID:
25784145
PMCID:
PMC4856012
DOI:
10.1002/bip.22639
[Indexed for MEDLINE]
Free PMC Article

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